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Updated: Jun 4, 2025

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对针对GPX4的TPD进行癌症治疗的概述

Xiaojuan Yang1, Liqiang Wu2, Shaohong Xu1

  • 1School of Pharmacy, Xinxiang University, Xinxiang 453003, China.

Bioorganic & medicinal chemistry
|December 18, 2024
PubMed
概括

向蛋白降解 (TPD) 提供了一种有希望的策略来诱导铁亡,这是一种细胞死亡途径,对癌症治疗至关重要. 针对GPX4的TPD显示出比传统抑制剂更强的选择性和有效性.

关键词:
这是一种抗瘤药物.葡萄氨酸过氧化酶 4 氨酸过氧化酶疏水标签 疏水标签是指疏水的标签.针对蛋白质溶解的嵌合体.有针对性的蛋白质降解降解.

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