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一项II期随机对照试验的生命质量分析,比较局部高级直肠癌患者的三维规范放射治疗和强度调节放射治疗.

R L Geary1, C Gillham1, G McVey1

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关键词:
3DCRT 3DCRT是指3DCRT是指3DCRT3DCRT是指3DCRT3DCRT3DCRT4在IMRT中,IMRT是IMRT.这是一种新辅助剂.人们的生活质量.放射疗法是一种放射治疗.这是直肠癌.

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科学领域:

  • 辐射瘤学 辐射瘤学
  • 胃肠道瘤学 胃肠道瘤学
  • 临床试验 临床试验

背景情况:

  • 新辅助放射治疗是局部晚期直肠癌的标准.
  • 三维合规放射疗法 (3DCRT) 和强度调节放射疗法 (IMRT) 是常见的技术.
  • 这些技术之间的生活质量 (QOL) 结果的比较对于患者护理至关重要.

研究的目的:

  • 在接受新辅助化疗或放射治疗的局部晚期直肠癌患者中,比较3DCRT和IMRT之间的QOL结果.
  • 评估不同放射治疗规划技术对患者幸福感的影响.

主要方法:

  • 一个II期随机试验,涉及94名患有局部晚期直肠癌的患者.
  • 患者接受了新辅助化学辐射疗法 (50.4 Gy) 与甲或capecitabine.
  • 随机分配到3DCRT或IMRT规划中的一个.
  • 使用EORTC QLQ-C30和QLQ-CR29在基线,放射治疗期间和放射治疗后六个月评估QOL.
  • 对基线得分进行调整的协差分析,以比较手臂之间的QOL.

主要成果:

  • 该试验因主要结果 (急性胃肠道毒性) 的徒劳而提前终止.
  • 总体而言,情绪功能有所改善,而身体,角色和社会功能在两组中都比基线下降.
  • 在放射治疗的最后一周,与3DCRT组相比,IMRT组的调整平均身体功能 (p=0.04) 和角色功能 (p=0.01) 得分明显更好.

结论:

  • 强度调节放射治疗 (IMRT) 对局部晚期直肠癌患者,与三维合规放射治疗 (3DCRT) 相比,在生活质量 (QOL) 方面表现出有限的优势.
  • 虽然IMRT的某些功能方面显示了暂时的益处,但整体的质量生活影响需要在更大的试验中进一步调查.