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由ZIF衍生多酶激活的光热增强铁性化疗

Changyu Cao¹, Da Bao Zha², Chencheng Sun³

¹Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM), School of Physical and Mathematical Sciences, Nanjing Tech University (NanjingTech), Nanjing 211816, China; School of Chemistry, Chemical Engineering and Biotechnology, Lee Kong Chian School of Medicine, Institute for Digital Molecular Analytics and Science, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459 Singapore.

Journal of colloid and interface science

|December 18, 2024

概括

一个新的单原子纳米酶结合光热疗法,化疗和纳米催化剂,有效地消除瘤. 这种多模式的方法通过铁和亡引发癌细胞死亡,副作用最小.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

开发用于协同治疗癌症的多功能纳米药物至关重要.
单原子纳米酶具有独特的催化和治疗潜力.
向瘤微环境 (TME) 提高了治疗效率.

研究的目的:

设计一个多功能单Fe-原子纳米酶 (Fe-SAzyme) 用于协同的癌症治疗.
整合近红外光热特性,化疗药物输送和多酶仿真.
调查TME中的合作纳米催化活动和光热效应.

主要方法:

一个Fe-原子纳米酶 (Fe-SAzyme) 的合成和表征.
在体外和体内评估Fe-SAzyme的治疗疗效.
研究包括铁亡,亡和光热效应在内的机制.
多克索鲁比 (DOX) 载荷和触发释放研究.

主要成果:

Fe-SAzyme 证明了过氧化酶,氧化酶和谷氨氧化酶的模仿性.
合作纳米催化产生了细胞毒性基因,诱导癌细胞铁亡.
光热效应增强了纳米催化剂,并使光热疗法成为可能.
DOX释放和Fe-SAzyme活动协同诱导癌细胞亡,导致完全消除瘤,没有显著的副作用.

结论:

设计的Fe-SAzyme提供了一个强大的多模式癌症治疗策略.
协同作用的铁灭,灭和光热疗法实现了完全的瘤根除.
这种纳米酶平台显示了针对性癌症治疗的承诺,并提高了安全性.

关键词:

化疗化疗是一种化学疗法.铁化是铁化的一种.纳米催化疗法是一种纳米催化疗法.光热疗法是一种光热疗法.单原子纳米酶是一种单原子纳米酶.

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