Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Drug Delivery: Overview01:16

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Drug Delivery Systems: Different Types01:27

Drug Delivery Systems: Different Types

Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Association between calcium-Sensing receptor gene polymorphisms and urinary calcium stone formation in the Han Chinese population from a High-Altitude region (Kunming) in China.

Urolithiasis·2026
Same author

Compact photoacoustic endoscopy by measuring initial photoacoustic pressure using phase-shift interferometry.

Photoacoustics·2025
Same author

Vitamin E-based prodrug self-delivery for nanoformulated irinotecan with synergistic antitumor therapeutics.

International journal of pharmaceutics·2020
Same author

Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes.

BMC cancer·2017
Same author

Analysis of the functions of the signal peptidase complex in the midgut of Tribolium castaneum.

Archives of insect biochemistry and physiology·2017
Same author

Influence of paeoniflorin and menthol on puerarin transport across MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model.

The Journal of pharmacy and pharmacology·2017

相关实验视频

Updated: Jul 20, 2026

High Throughput Single-cell and Multiple-cell Micro-encapsulation
16:19

High Throughput Single-cell and Multiple-cell Micro-encapsulation

Published on: June 15, 2012

18.6K

多个阶段的微流体辅助联合交付平台,用于双剂容易顺序封装.

Shixin Li1, Bing Yang2, Liang Ye1

  • 1School of Traditional Chinese Pharmacy, China Pharmaceutical University, 211198 Nanjing, Jiangsu, PR China.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
|December 18, 2024
PubMed
概括

一个新的微流体平台使多种具有不同性质的多种药物的顺序封装成为混合纳米粒子 (HNP). 这种先进的纳米药物输送系统显示了改善抗瘤疗法的前景.

关键词:
联合交付 联合交付微流体芯片是一个微流体.纳米晶体纳米晶体的使用纳米沉是一种纳米沉.顺序封装的封装方式

更多相关视频

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery
10:51

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery

Published on: August 7, 2014

8.6K
Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses
09:43

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

Published on: March 8, 2024

1.6K

相关实验视频

Last Updated: Jul 20, 2026

High Throughput Single-cell and Multiple-cell Micro-encapsulation
16:19

High Throughput Single-cell and Multiple-cell Micro-encapsulation

Published on: June 15, 2012

18.6K
Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery
10:51

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery

Published on: August 7, 2014

8.6K
Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses
09:43

Author Spotlight: Unveiling the Polyfunctionality and Heterogeneity in Immune Responses

Published on: March 8, 2024

1.6K

科学领域:

  • 纳米医学是一种纳米医学.
  • 材料科学 材料科学 材料科学
  • 化学工程是化学工程的重要组成部分.

背景情况:

  • 在一个纳米药物载体中集成多种治疗剂是具有挑战性的,因为它具有不同的物理化学性质.
  • 有效的抗瘤疗法需要先进的药物输送系统,能够处理复杂的药物组合.

研究的目的:

  • 开发一种新的多阶段微流体平台,用于对具有不同物理化学性质的药物的连续联合封装.
  • 合成和描述载有各种药物组合的混合纳米粒子 (HNP).

主要方法:

  • 使用多级微流体TrH芯片进行序列纳米沉.
  • 合成的混合纳米粒子 (HNPs) 装载着帕克利塔塞尔 (PTX) - 西姆瓦斯塔丁 (SV),PTX-伦瓦提尼布 (LV) 和SV-LV.
  • 对于结构,颗粒大小,封装效率和药物加载效率来说,HNP的特征.

主要成果:

  • 实现了核心结构的HNP,具有均的颗粒大小分布,超越了传统方法.
  • 在各种比率上证明了近100%的封装效率,用于双重药物加载.
  • 对于PTX-SV/HNP (14.97%),PTX-LV/HNP (16.58%) 和SV-LV/HNP (19.21%) 的量化高药物负载效率.
  • 在体外证实PTX-SV/HNP的连续药物释放 (SV和PTX).
  • 与单个药物相比,PTX-SV/HNPs对HepG2细胞的细胞毒性更强.

结论:

  • 多级微流体平台有效地将具有显著物理化学差异的药物共同封装在一起.
  • 开发的HNP为纳米医学中先进的多药物输送提供了强大的战略.
  • 这种方法在增强抗瘤疗法方面具有重大潜力.