牛奶骨素具有高的铁结合能力,并促进肠道细胞的铁吸收
Emilie H Buhl1, Brian Christensen1, Freja H Pedersen1
1Department of Molecular Biology and Genetics, Aarhus University, 8000 Aarhus C, Denmark.
Journal of dairy science
|December 18, 2024
概括
牛奶蛋白质的骨质素 (OPN) 有效地结合并提供铁,以便在肠道细胞中吸收. 这种蛋白质增强铁的吸收,即使饮食抑制剂存在,提供了一个新的输送系统.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 细胞生物学 细胞生物学
背景情况:
- 由于饮食中铁的吸收不足,缺铁会给健康带来重大风险.
- 开发有效的铁输送系统对于提高铁的生物可用性和吸收至关重要.
- 已知牛奶蛋白质的骨质素 (OPN) 能够结合矿物质,并且可以通过肠道屏障进行运输.
研究的目的:
- 调查牛奶骨质素 (OPN) 作为食铁的潜在载体.
- 评估OPN提高肠道细胞中铁的吸收的能力.
- 评估OPN在胃肠道消化过程中的稳定性和铁结合性.
主要方法:
- 研究了全长OPN及其碎片的铁结合能力.
- 在模拟胃肠道消化后评估铁的保留.
- 在Caco-2细胞中评估细胞铁吸收,使用费里丁形成和双价金属载体的mRNA表达1.
- 在铁吸收抑制剂植物酸存在的情况下测试了OPN的疗效.
主要成果:
- OPN及其碎片表现出显著的铁结合能力,其中酸化残留物至关重要.
- 在模拟胃肠道消化后,OPN-铁复合体保持稳定,并且对素消化表现出更强的抗性.
- OPN显著增强了肠道细胞的细胞铁吸收,即使存在植物酸.
结论:
- 骨质疏松素 (OPN) 作为一种有效的铁载体,促进铁的增强吸收.
- 在胃肠道条件下,OPN-铁复合物是稳定的,这表明它适合于口服.
- OPN提出了一项有前途的战略,旨在开发新的,生物可利用的铁输送系统,以对抗铁缺乏症.
更多相关视频
08:45Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes
Published on: May 10, 2022
1.9K
06:47Isolation of Mesenchymal Stem Cells from Human Alveolar Periosteum and Effects of Vitamin D on Osteogenic Activity of Periosteum-derived Cells
Published on: May 4, 2018
9.3K
相关概念视频
Hormones and Bone Tissue
2.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.6K
The Early Endosome: Endocytosis of Transferrin
3.2K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
3.2K
Role of Vitamins in Maintaining Bone Health
3.1K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.1K
Antimicrobial Proteins
893
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
893
Protein Absorption
119
Proteins in the gastrointestinal tract typically come from food, but they can also originate from disintegrated cells or secreted enzymes. In the stomach, the enzyme pepsin breaks down these proteins into polypeptides. The fragments then move into the duodenum as a semi-fluid mass called chyme. Pancreatic proteases, such as trypsin and chymotrypsin, and intestinal brush border enzymes like carboxypeptidases further dismantle the polypeptides into tripeptides, dipeptides, and free amino acids.
119
Essential Minerals for Bone Health
3.8K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
3.8K
