肥胖相关并发病的改善5年内镜袖胃口塑造后:一个前性队列研究
Ali Lahooti1, Donevan Westerveld1, Kate Johnson1
1Division of Gastroenterology and Hepatology, Department of Medicine, Weill Cornell Medicine, New York, New York, USA.
Gastrointestinal endoscopy
|December 18, 2024
概括
内镜套管胃形成术 (ESG) 有效治疗肥胖和相关疾病5年. 这种微创手术显著改善了代谢标志物,并实现了显著的体重减轻,具有良好的安全性.
科学领域:
- 腹腔内镜检查 腹腔内镜检查 腹腔内镜检查
- 代谢手术 代谢手术
- 胃肠病学 胃肠病学
背景情况:
- 内镜套胃形成术 (ESG) 是一种用于减肥的微创性减肥手术.
- 关于ESG作为肥胖相关并发症单一治疗的长期数据有限.
研究的目的:
- 评估ESG作为单一疗法对与肥胖相关的并发症的长期 (5年) 影响.
- 评估人体特征,临床参数,代谢生物标志物和ESG后的肝功能测试的变化.
主要方法:
- 对404名接受ESG治疗的患者进行前性研究 (BMI≥30或≥27kg/m2并发症).
- 排除接受辅助治疗的患者,以评估ESG作为单疗法.
- 12,36和60个月的后续评估评估了人体测量,临床,代谢和肝功能参数.
主要成果:
- 5年后,血红蛋白A1c (Δ -0.42%),静脉血压 (Δ -4.1 mm Hg) 和氨酸转移酶 (Δ -7.4 U/L) 的显著降低.
- 平均BMI从手术前的37.5 ± 5.8 kg/m2下降到60个月后的33.8 ± 6.7 kg/m2 (P < .001).
- 5年后,总体体重减轻 (TBWL) 为11.8%,有3次中度不良事件 (0.7%).
结论:
- ESG是一种有效的,非侵入性的单疗法,用于管理肥胖和相关的并发症.
- 该程序在5年内表明高血压,糖尿病和与代谢功能障碍相关的脂肪性肝病的标志物持续改善.
- 通过ESG,可以实现显著而持久的全身体重减轻.
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