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反复暴露于低强度噪声会通过RAGE信号通路加剧与年龄相关的听力损失

Jianbin Sun¹, Na Sai², Tong Zhang²

¹Senior Department of Otorhinolaryngology Head and Neck Surgery, The 6th Medical Center, Chinese PLA General Hospital, Medical School of Chinese PLA, State Key Laboratory of Hearing and Balance Science, National Clinical Research Center for Otorhinolaryngologic Diseases, Beijing 100048, China; Department of Otorhinolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi Provincial Key Laboratory for Precision Diagnosis and Treatment of Otorhinolaryngology, Xi'an 710004, China.

Neurobiology of disease

|December 18, 2024

概括

重复暴露于低强度噪声,导致暂时值转移 (TTS),加速与年龄相关的听力损失. 针对RAGE通路可能会防止噪音引起的听力损伤和减缓衰老效应.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
神经科学是一个神经科学.
老年学是一门学科.

背景情况:

在现代社会中,反复暴露于低强度噪音是很常见的.
由于暴露于噪音而导致的临时值转移 (TTS) 可能是听力损失的危险因素.
对于TTS对与年龄相关的听力衰退的长期影响尚未完全理解.

研究的目的:

调查重复低强度噪音暴露如何导致听力损伤.
检查噪声诱导的TTS对与年龄相关的听力损失进展的影响.
探索潜在的治疗目标,以减轻噪音引起的听力损伤.

主要方法:

C57BL/6J小鼠被暴露在白噪声 (96dB SPL,8h/day,7天) 中以诱导TTS.
听觉脑干反应 (ABR) 用于监测听力值长达12个月.
进行了蛋白质组学分析,耳液分析和组织学检查.

主要成果:

暴露于噪音的小鼠表现出加速高至低频率与年龄相关的听力损失.
观察到RAGE通路的升调,与炎症和血管损伤有关.
小鼠表现出耳炎症,血液迷宫屏障的超透性和细胞损伤 (线粒体,突触).

结论:

重复暴露于低强度噪音和TTS与严重的与年龄相关的感觉神经神经听力损失相关.
噪音暴露会损害耳部件,增加与年龄相关的压力的易感性.
针对RAGE信号通路显示出减轻噪声引起的听力损伤和减缓与年龄相关的听力损失的前景.

关键词:

衰老的衰老衰老的衰老听力损失听力损失神经退行发生神经退行.神经炎症是一种神经炎症.噪声噪声噪声愤怒的愤怒愤怒的愤怒

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