细菌纤维素/硫化化纳米颗粒混合抗微生物包裹用于黄素输送
Julen Diaz-Ramirez1, Senda Basasoro1, Stefano Torresi1
1'Materials+Technology' Group, Engineering School of Gipuzkoa, Department of Chemical and Environmental Engineering, University of the Basque Country (UPV/EHU), Pza. Europa 1, 20018, Donostia-San Sebastián, Spain.
International journal of biological macromolecules
|December 18, 2024
概括
装载着黄素的酸化纳米颗粒被整合到细菌纤维素膜中. 这种新的复合物增强了黄素的功效.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物运输 药物运输 药物运输
背景情况:
- 酸 (Cs) 具有有限的溶解性和粘附性,阻碍其生物医学应用.
- 黄素具有强大的治疗性质,但其生物可用性较差.
- 细菌纤维素 (BC) 膜提供了一个生物相容的支架,但需要功能化来提高性能.
研究的目的:
- 为了合成化基 (Cs-SH) 纳米颗粒,以提高基的性能.
- 将黄素加载到Cs-SH纳米粒子 (Cur-Cs-SH) 中,以提高其生物可用性.
- 将Cur-Cs-SH纳米粒子纳入细菌纤维素 (BC) 膜,用于先进的生物医学应用.
主要方法:
- 用真空辅助封闭方法将Cs-SH纳米粒子集成到BC膜中.
- 进行了纳米粒子合成和表征 (大小,稳定性).
- 进行了体外释放研究,粘附测试 (猪皮,猪皮) 和抗菌检测.
主要成果:
- 硫化剂增强了基托的溶解性和粘附性; Cs-SH纳米粒子大小为121 ± 2 nm.
- 库尔库加载导致Cur-Cs-SH纳米颗粒152 ± 6nm,稳定性得到改善.
- BC膜实现了99%的纳米粒子保留,证明了pH取决于药物释放和增强粘附.
- 观察到对S. aureus和E. coli的协同抗微生物活性.
结论:
- 开发的结合Cur-Cs-SH纳米颗粒的BC膜显示了增强的粘附性和受控的药物释放.
- 增加黄素的生物可用性和协同抗菌作用扩大了潜在的生物医学应用.
- 这种功能化的BC膜平台对向药物输送和组织工程具有前景.
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