对Xanthoceras sorbifolium bunge种子核的毒性影响和安全性评估
Wen Zhou1, Shi-Bo Lyu1, Hui Li1
1Division of Toxicology, Shandong Center for Disease Control and Prevention, Jinan, 250014, China; Shandong Provincial Key Medical And Health Discipline of Sanitary Analysis (Shandong Center For Disease Control And Prevention), Jinan, 250014, China.
Journal of ethnopharmacology
|December 18, 2024
概括
桑托塞拉斯豆种子在推剂量下安全食用,具有潜在的抗炎和抗氧化特性. 为临床应用鼓励进一步的研究.
科学领域:
- 药理学和毒理学 药理学和毒理学
- 传统中国医药 传统中国医药
- 营养保健品 营养保健品
背景情况:
- 桑托塞拉 (X. sorbifolia) 是一种中国的油作物,具有食用和药用用途,以抗氧化和抗炎性质而闻名.
- X. sorbifolia的种子核被广泛消费,但它们的毒性概况需要彻底调查.
研究的目的:
- 评估X. sorbifolia种子核的急性毒性和安全性,在人体推剂量下.
- 探索X. sorbifolia种子核的生物功能和抗炎作用,使用体外,体内和网络分析.
主要方法:
- 在使用各种基因毒性和90天暴露研究的老鼠和小鼠中评估了急性毒性.
- 网络分析整合了来自比较毒基因组学数据库 (CTD) 的数据,以确定基因相互作用.
- 通过在老鼠身上使用棉球颗粒瘤试验来研究抗炎作用.
主要成果:
- 动物在所有治疗组都表现出正常的生长和发育,没有显著的不良影响.
- 网络分析确定了120个参与氧化应激和炎症反应途径的目标基因.
- X. sorbifolia通过抑制颗粒瘤扩散,显示出潜在的抗炎和抗氧化特性.
结论:
- 在推剂量范围内,X. sorbifolia种子核被认为是安全的.
- 这项研究证实了X. sorbifolia的抗炎和抗氧化潜力,支持其在传统医疗中使用.
- 这些发现为临床使用提供了指导方针,并鼓励进一步研究X. sorbifolia的治疗应用.
相关概念视频
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In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
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