在潜伏性结核病的预防治疗期间因伊索尼亚齐德引起的急性肝衰竭:一个罕见的尸体解剖案例报告
Yuka Yamazaki1, Keiichi Tominaga1, Takahiro Arisaka1
1Department of Gastroenterology, Dokkyo Medical University School of Medicine, Japan.
Internal medicine (Tokyo, Japan)
|December 18, 2024
概括
潜伏性结核病感染 (LTBI) 用异化 (INH) 治疗可以预防结核病,但存在肝损伤的风险. 本病例报告详细介绍了因INH治疗而导致致命的急性肝衰竭的患者.
科学领域:
- 内部医学 内部医学
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
背景情况:
- 潜在结核病感染 (LTBI) 治疗对于预防活跃结核病至关重要.
- 异化 (INH) 是推的LTBI的第一线治疗方法,通常为6-12个月.
- 肝毒性是已知的异化治疗的不良影响.
研究的目的:
- 报告一个尸检案例致命的异尼胺诱导的肝毒性.
- 为了突出与LTBI治疗相关的风险.
主要方法:
- 案例报告的呈现方式.
- 尸体解剖的发现.
- 审查患者的病史和治疗方法.
主要成果:
- 一名被诊断患有LTBI的65岁男性接受了异化治疗.
- 患者出现了急性肝衰竭.
- 尸体解剖证实异胺诱导的肝损伤是死亡的原因.
结论:
- 异化治疗虽然对LTBI有效,但可能导致严重的肝毒性.
- 在伊索尼亚治疗期间,密切监测肝功能至关重要.
- 这一案例强调了风险-收益评估在LTBI管理中的重要性.
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