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Updated: Jun 4, 2025

Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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USP33 调节DNA损伤反应和致癌症通过降解和稳定p53来调节

Yuqi Zhu1,2,3, Zixiang Chen1,2, Kaifeng Niu1,2

  • 1China National Center for Bioinformation, Beijing, China.

Cell proliferation
|December 18, 2024
PubMed
概括

脱基酶USP33稳定了瘤抑制剂p53,增强了DNA损伤反应. USP33表现出抗瘤活性,这是通过在淘汰赛小鼠中减少肝癌发生的证据.

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