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Dosage Regimen: Fixed Dose01:01

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Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
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In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
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Drug Dosage Regimen: Overview01:15

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A drug dosage regimen describes the specific instructions and schedule for administering a drug to a patient. It considers factors such as drug dosage, frequency, route of administration, and duration of treatment. Designing an appropriate dosage regimen for a patient aims to achieve a target drug concentration at the site of action.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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[Translated article] Real-world evidence of immune-related adverse events as predictive factor of response in non-small cell lung cancer.

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Updated: Jun 4, 2025

Pretargeted Radioimmunotherapy Based on the Inverse Electron Demand Diels-Alder Reaction
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免疫疗法中的固定剂量或体重调整剂量?

Marca Diaz-Rangel1, Francisca Sanchez-Rubio2, Andrea Drozdz-Vergara3

  • 1Pharmacy, Hospital General de Albacete, Albacete, Spain marcad@sescam.jccm.es.

European journal of hospital pharmacy : science and practice
|December 18, 2024
PubMed
概括
此摘要是机器生成的。

固定剂量免疫检查点抑制剂导致严重的药物过量和成本增加. 体重调整剂量提供了实质性的经济节约,并且越来越多地在西班牙医院采用,提高治疗优化.

关键词:
抗瘤剂 抗瘤剂 抗瘤剂临床医学 临床医学造价效益分析 造价效益分析经济学,药品制造业药房服务,医院服务.

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科学领域:

  • 在瘤学瘤学.
  • 药物经济学 药物经济学
  • 医院 医院 药房 医院药房

背景情况:

  • 免疫检查点抑制剂 (ICI) 在癌症治疗中至关重要.
  • 目前的固定剂量方案可能导致低于最佳剂量和增加医疗保健支出.
  • 在医疗保健机构中存在ICI剂量实践的变化.

研究的目的:

  • 分析固定剂量ICI的经济影响.
  • 为了确定重量调整剂量的潜在成本节约.
  • 描述西班牙医院当前的ICI剂量实践.

主要方法:

  • 对297名接受ICI (pembrolizumab,nivolumab,avelumab,durvalumab,cemiplimab) 的患者进行了回顾性多中心观察性研究.
  • 分析临床和经济变量,包括药物成本,过量剂量百分比和机会成本.
  • 在西班牙医院对ICI剂量方案选择进行匿名调查.

主要成果:

  • 确定了固定剂量ICI的重大机会成本:潘布罗利祖马布 (615.316欧元),尼沃卢马布 (486.327欧元).
  • 体重调整剂量在54.7%的病例中部分实施,通常由药房和瘤服务部门决定.
  • 调查显示,西班牙各医院的ICI剂量方案存在差异.

结论:

  • 固定剂量ICI导致药物过量服用和与体重调整剂量相比,对预算产生相当大的影响.
  • 通过体重调整剂量的治疗优化提供了潜在的预算节省.
  • 西班牙的医疗保健实践显示了ICI剂量的变化,突出了优化需求.