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通过基于补充和转移素的冠状病毒蛋白向髓性白血病细胞提供双重向药物

Wen Wu^1,2, Yuanyuan Li¹, Qihui Liu¹

¹State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, Key Laboratory of Pathobiology, Ministry of Education, Nanomedicine and Translational Research Center, China-Japan Union Hospital of Jilin University, Changchun 130033, P. R. China.

|December 18, 2024

概括

具有聚合蛋白 (NAP) 的纳米粒子为向急性髓性白血病 (AML) 提供了一种新的方法. NAPs增强白血病细胞的药物吸收,同时最大限度地减少非目标效应,显示AML治疗的希望.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
在瘤学瘤学.

背景情况:

经常被视为障碍的蛋白质冠状体可以被利用用于有针对性的药物输送.
由于特定的细胞表面标记物,急性髓性白血病 (AML) 在向治疗中存在挑战.

研究的目的:

开发和评估含有聚合蛋白 (NAP) 的纳米颗粒,以向AML细胞.
评估NAP在向白血病细胞输送多克索鲁比辛 (DOX) 的疗效和特异性,在体外和体内.

主要方法:

工程纳米颗粒与聚合转激素和C3b (NAPs) 向CD71和CD11b受体.
评估的DOX吸收和非目标积累在白血病和正常细胞在体外.
在NSG小鼠模型中评估NAP生物分布和抗白血病活性 (体内).

主要成果:

与免费药物 (6.19%) 相比,NAP在白血病细胞中实现了显著更高的多克索鲁比辛吸收 (73.9%).
在正常细胞中,非目标积累从NAPs的42.9%降至5.76%.
与白血病细胞透相关的NAP分布;通过透和ferroptosis在体外和体内证明了抗白血病活性.

结论:

通过NAP介导的药物输送是提高AML治疗疗效的有希望的策略.
这种方法可以更好地准白血病细胞,并减少全身毒性.

关键词:

急性骨髓性白血病 (AML) 是一种急性骨髓性白血病.细胞表面准,蛋白质冠状冠状补充元件 C3b 补充元件 C3b 装载药物的纳米粒子.转移林是一种转移素.

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