与SARS-CoV-2相关的晚期儿科乳腺炎,通过组织学分析证实
Koji Yokoyama1, Yasuharu Sato2, Yuka Suimon3
1Paediatrics, Japanese Red Cross Society, Minato-ku, Tokyo, Japan kojiy@kuhp.kyoto-u.ac.jp.
BMJ case reports
|December 18, 2024
概括
本案例研究详细介绍了与SARS-CoV-2感染相关的儿童慢性乳腺炎. 组织学分析证实了病毒存在.
科学领域:
- 眼科医生 眼科 眼科
- 传染性疾病 传染性疾病
- 病理学 病理学 病理学
背景情况:
- SARS-CoV-2 (严重急性呼吸系统综合征冠状病毒2) 除了呼吸系统症状之外,可以呈现出各种不同的临床表现.
- 乳腺炎,眼腺炎,是一种不太常见的并发症.
- 了解病毒感染和眼部炎症状况之间的联系对于全面的患者护理至关重要.
研究的目的:
- 报告与之前的SARS-CoV-2感染相关的慢性乳腺炎病例.
- 调查将SARS-CoV-2与眼腺炎症联系在一起的潜在病原遗传机制.
- 为了突出SARS-CoV-2感染的蛋白质并发症.
主要方法:
- 一个学龄男孩的临床表现和病史,双边眉毛胀和眼疼痛.
- 用加多增强的T1加权核磁共振成像来评估眼腺形态.
- 临床病理学分析包括组织学检查和免疫组织化学检查眼腺组织中的SARS-CoV-2核囊蛋白.
- 对SARS-CoV-2的眼液进行PCR测试.
主要成果:
- 双边慢性乳腺炎在组织学上得到证实.
- 核磁共振扫描显示了眼腺扩大.
- 眼腺中的炎症细胞对SARS-CoV-2核囊蛋白显示出免疫活性.
- 眼液的SARS-CoV-2 PCR测试结果是负的.
- 该患者有轻度呼吸道症状的病史,并在达克里奥腺炎发病前3个月的SARS-CoV-2抗原测试中呈阳性.
- 用局部类固醇治疗导致2个月的缓慢缓解和10个月的临床稳定性.
结论:
- 这一案例表明SARS-CoV-2感染和慢性乳腺炎的发展之间可能存在关联.
- 在炎症细胞中存在SARS-CoV-2核体蛋白质,支持病毒在病变发生过程中直接或间接发挥作用.
- 在有SARS-CoV-2感染史的患者中,应考虑眼部炎症并发症.
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