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Updated: Jun 4, 2025

Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells
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Multiplexed Immunofluorescence Analysis and Quantification of Intratumoral PD-1+ Tim-3+ CD8+ T Cells

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评估免疫检查点抑制剂对CD274固体瘤 (PD-L1基因) 放大效果的有效性,通过综合基因组分析确定:基于全国数据库的回顾性研究

Tomohiro Nakayama1,2, Takayuki Takahama3,4, Yasutaka Chiba5

  • 1Medical Oncology, Kishiwada City Hospital, Kishiwada, Japan.

Journal for immunotherapy of cancer
|December 18, 2024
PubMed
概括

固体瘤中编程细胞死亡-配体1基因 (CD274) 放大可能预测对免疫检查点抑制剂 (ICI) 的反应. 这项迄今为止最大的分析表明,CD274放大可能是ICI疗效的生物标志物.

关键词:
生物标志物生物标志物免疫检查点抑制剂 免疫检查点抑制剂固体瘤是一个固体瘤.

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Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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