短链脂肪酸在胎儿发育和新陈代谢中的作用
Xueyun Qin1, Mo Zhang1, Shiting Chen1
1Obstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, China; Shanghai Key Laboratory of Reproduction and Development, Shanghai, China.
母亲的肠道微生物产生短链脂肪酸 (SCFA),这对胎儿发育至关重要. 孕产妇的代谢障碍会破坏SCFA,可能会损害后代的健康和发育.
科学领域:
- 围产学和发育生物学,专注于肠道微生物群的代谢影响.
背景情况:
- 由肠道微生物群产生的短链脂肪酸 (SCFA) 对胎儿发育至关重要.
- 母亲的SCFA水平受到饮食和代谢健康的影响,通过胎盘传递给胎儿.
- 糖尿病和肥胖等孕产妇代谢障碍会破坏SCFA概况,影响胎儿的代谢编程.
研究的目的:
- 审查最近关于母性SCFA在后代代谢编程中的作用的进展.
- 通过SCFA探索母亲代谢障碍对胎儿发育的影响.
- 突出SCFA作为子宫内风险因素的潜在治疗点.
主要方法:
- 关于SCFA,母亲新陈代谢和胎儿发育的当前研究的文献综述.
- 在SCFA运输和信号中对胎盘-胚胎轴的分析.
- 检查母亲代谢应激对后代结果的影响.
主要成果:
- 孕产妇的SCFA显著影响胎儿的代谢重编程.
- 由于代谢压力而导致失调的孕产妇SCFA可能会对胎儿的心血管,神经和免疫系统发育产生负面影响.
- 改变的SCFA水平与后代的不良成年健康结果有关.
结论:
- 孕产妇的SCFA是胎儿发育的关键调解者.
- 有针对性的SCFA补充可能提供一种策略,以减轻与母亲代谢障碍相关的发育风险.
- 了解胎盘-胚胎轴是利用SCFA提高围产期健康的关键.
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