在初级全关节关节生长中,在关节内应用后,对全系统血清万科米辛水平的分析
Stauss R1, Savov P2, Seeber Gh2,3
1School of Medicine and Health Sciences, Division of Orthopaedics at Campus Pius-Hospital, Carl von Ossietzky Universität Oldenburg, Georgstraße 12, 26121, Oldenburg, Germany. ricarda.stauss@uni-oldenburg.de.
Archives of orthopaedic and trauma surgery
|December 18, 2024
概括
在初级全关节整形术 (TJA) 中,关节内万科米辛粉末没有导致在治疗范围内的全身度. 这表明,万科米辛粉是预防周围假肢关节感染 (PJI) 的安全补充剂.
科学领域:
- 整形外科手术 整形外科手术
- 预防传染病 预防传染病
- 药理学 药理学是指药理学的学科.
背景情况:
- 周围假肢关节感染 (PJI) 是全面关节整形术 (TJA) 的严重并发症,导致显著的发病率,死亡率和医疗费用.
- 在手术期间,越来越多地用于PJI预防初级全关节整形手术 (THA) 和全膝关节整形手术 (TKA).
- 有限的数据存在于系统的万科米辛水平和药物不良反应 (ADR) 后的关节内应用.
研究的目的:
- 在初级TJA中,在关节内给药后检查全身万科米辛水平.
- 评估与关节内万科米辛使用相关的潜在不良药物反应 (ADR).
主要方法:
- 对103名接受初级THA或TKA治疗的患者进行前性试点研究.
- 在伤口关闭之前,在关节内施加1克万科米辛粉末.
- 术后24小时和48小时测量出的血清米素水平.
主要成果:
- 与24小时和48小时的TKA相比,在THA患者中观察到较高的平均血清万科米辛水平 (分别p<0.001和p=0.044).
- 平均THA水平:24小时1.25微克/毫升,48小时0.34微克/毫升;TKA患者没有可检测的全身水平.
- 没有万科米辛度达到治疗水平,也没有报告任何不良药物反应.
结论:
- 在初级TJA中,关节内万科米辛粉末不会导致显著的全身吸收.
- 这些发现表明,关节内万科米辛粉是预防PJI的安全和潜在的成本效益方法.
- 进一步的研究可能会证实其在PJI预防策略中的辅助作用.
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