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Updated: Jun 4, 2025

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CB1R与外围和偏向逆agonists结合的结构机制

Punita Kumari1,2, Szabolcs Dvorácskó3,4,5,6, Michael D Enos1

  • 1Department of Biophysics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Nature communications
|December 18, 2024
PubMed
概括

新的外围受限大麻素受体1 (CB1R) 逆agonists,MRI-1867和MRI-1891,提供代谢益处没有中央精神病学副作用. 冷电磁结构揭示了它们的结合机制,使得更安全的治疗开发成为可能.

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