肠道微生物群-炎症-大脑轴在未经药物治疗的双相情绪障碍II型抑郁症中受到破坏
Zixuan Guo1,2, Shu Xiao1,2, Guanmao Chen1,2
1Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China.
Translational psychiatry
|December 18, 2024
概括
这项研究揭示了变化的肠道细菌和双相II型抑郁症的炎症,影响大脑连接. 这些肠-大脑轴的变化为双相情感障碍机制提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 微生物学 微生物学
背景情况:
- 肠道微生物群-炎症-大脑轴与精神健康障碍有关.
- 它在抑郁两极性障碍 (BD) 中的具体作用需要进一步阐明.
研究的目的:
- 为了调查肠道微生物群,炎症和大脑连接在未经药物治疗的双相II型疾病 (BD II) 患者.
- 探索这些因素在BD II抑郁症的病理生理学的相互作用.
主要方法:
- 招募了65名无药BD II患者和58名健康对照 (HC).
- 获得的静止状态功能性MRI数据用于低频波动 (ALFF) 和功能连接 (FC) 的静态和动态振幅.
- 通过16S rRNA测序分析了肠道微生物组合,并测量了血清细胞因子水平.
主要成果:
- 在BD II患者中,左小脑Crus II的静态ALFF减少.
- 观察到小脑静态和动态功能连接性与右下叶和上额头回形的功能连接性下降.
- 在BD II患者中发现了增加的促炎和抗炎细胞因子,以及增加的促炎细菌和改变的微生物代谢 (谷氨酸,GABA).
- 在左大脑Crus II.中,Parabacteroides水平和IL-8水平之间的显著相互作用独立地预测了静态ALFF.
结论:
- 肠道微生物群-炎症-大脑轴在抑郁型BD II中发生显著变化.
- 特定的肠道细菌和炎症标志物与小脑中的大脑连接性变化有关.
- 这些发现提供了对BD II抑郁症背后的病理生理机制的更深入的理解.
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