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Updated: Jun 4, 2025

Assaying Proteasomal Degradation in a Cell-free System in Plants
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SMURF1和SMURF2直接针对GLI1进行无处不在和蛋白酶体依赖的降解

Fabio Bordin1, Gloria Terriaca1, Adriano Apostolico1

  • 1Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.

Cell death discovery
|December 18, 2024
PubMed
概括

SMURF1和SMURF2准GLI1,这是刺通路中的关键蛋白质,用于降解. 这种作用抑制了瘤细胞的增殖,为驱动的癌症提供了潜在的治疗策略.

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