在肥胖的年轻成年人中改变了灰色物质的结构共变网络
1School of Mental Health, Zhejiang Provincial Clinical Research Center for Mental Health, The Affiliated Wenzhou Kangning Hospital, Wenzhou Medical University, Wenzhou, China. huixujx@gmail.com.
International journal of obesity (2005)
|December 18, 2024
概括
肥胖会改变年轻人的大脑结构网络. 结构共变网络 (SCN) 显示皮质厚度和表面积的变化,影响关键的大脑区域和网络.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 肥胖与异常的大脑功能网络有关.
- 在肥胖中使用皮质厚度 (CT) 和皮质表面积 (CSA) 的结构共变网络 (SCN) 的变化仍然不清楚.
研究的目的:
- 调查肥胖的年轻人和瘦个体之间的SCN差异.
- 用CT和CSA探索肥胖对大脑结构的影响.
主要方法:
- 243名肥胖的年轻成年人和243名瘦弱的对照人来自人类连接组项目数据集.
- 磁共振成像 (MRI) 扫描和神经心理评估.
- 使用大脑连接工具箱构建的SCN矩阵;用于组比较的非参数顺序测试.
主要成果:
- 肥胖个体显示左下肠内皮层CSA和特定区域的CT变化 (例如,正面前环皮层,上顶叶,极).
- 在全球网络措施中没有发现显著差异.
- 在大脑的广泛区域发现了节点网络测量中的显著变化,包括后带带皮质,上额头,内皮质和内侧皮质.
结论:
- 肥胖的年轻人表现出与默认模式,中央执行和突出网络相关的大脑区域的异常节点网络测量.
- 这些发现表明,肥胖通过三重网络的改变对年轻人产生不利影响,影响大脑连接.
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