在患有严重抑郁症的患者中,psilocybin增加了情感同情心
J Jungwirth1, R von Rotz2, I Dziobek3
1Department of Adult Psychiatry and Psychotherapy, Psychiatric University Clinic Zurich and University of Zurich, Zürich, Switzerland. johannes.jungwirth@pukzh.ch.
Molecular psychiatry
|December 18, 2024
概括
西治疗改善了抑郁症患者的同情心,特别是对积极经历的同情心. 这表明迷幻药可能会增强抑郁症患者的社会认知能力.
科学领域:
- 精神病学和神经科学 精神病学和神经科学
- 临床心理学 临床心理学
- 迷幻研究 迷幻研究
背景情况:
- 共感对于人际关系和心理健康至关重要,但在抑郁症中往往会减弱.
- 西显示出对抑郁症治疗的潜力,并且在健康个体中急剧增强了同情心.
- 西对临床抑郁症患者的同理心的影响仍未得到充分研究.
研究的目的:
- 为了研究西辅助治疗对患有严重抑郁症的患者同情心的持久影响.
- 为了确定psilocybin是否增强了社会认知及其与改善症状的相关性.
主要方法:
- 一个随机的,安慰剂对照试验,涉及51名抑郁症患者.
- 在为期4周的心理支持干预中,参与者接受了单剂量psilocybin (0.215 mg/kg) 或安慰剂.
- 在基线和2天,1周和2周后使用多方面的同情测试来评估同情心.
主要成果:
- 与安慰剂相比,接受psilocybin的患者在明确的情感同理心方面表现出显著的改善.
- 这种增强主要是由于对积极刺激的同理心增加.
- 对同理心的积极影响在治疗后至少持续了两周.
结论:
- 在患有抑郁症的个体中,psilocybin辅助疗法显示出增强社会认知,特别是情感同理心的潜力.
- 这些发现有助于理解精神乱药在治疗抑郁症中的作用的心理机制.
- 进一步的研究是有必要的,以探索增强的社会认知和心理治疗中临床结果之间的相互作用.
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