细胞外CIRP作为慢性阻塞性肺病结合肺高血压的内皮功能障碍的预测标记
Yun Yao1, Haibo Jiang1, Dalin Xu1
1Department of Respiratory and Critical Care Medicine, Anhui Provincial Lujiang County People's Hospital, Hefei, Anhui, P.R. China.
细胞外冷诱导性RNA结合蛋白 (eCIRP) 在COPD-PH中升高,与炎症和内皮功能障碍相关. 作为预测这种情况的生物标志物,eCIRP显示出希望.
科学领域:
- 肺部医学 肺部医学
- 心血管研究研究心血管研究
- 分子生物学分子生物学
背景情况:
- 肺高血压 (PH) 是慢性阻塞性肺病 (COPD) 的严重并发症,其特征是肺内皮功能障碍.
- 细胞外冷诱导性RNA结合蛋白 (eCIRP),一种与损伤相关的分子模式 (DAMP),加剧了COPD-PH的炎症和血管内皮功能障碍.
研究的目的:
- 调查eCIRP在COPD-PH中的作用.
- 为了比较血清中的eCIRP水平,炎症标志物和内皮功能障碍指标在患有和没有PH的COPD患者中.
- 评估eCIRP在诊断COPD-PH.PH.方面的预测价值.
主要方法:
- 在40个个人的肺组织中比较CIRP表达.
- 在150名COPD患者和50名对照人群中对血清CIRP,IL-1β,IL-33,ET-1和NO水平进行了前性分析.
- 利用ROC曲线分析来评估COPD-PH血清标志物的诊断和预测价值.
主要成果:
- 与COPD非PH和正常对照相比,COPD-PH患者的肺组织中观察到较高的CIRP水平.
- 在COPD-PH中,血清CIRP,IL-1β,IL-33和ET-1水平显著升高,NO水平降低.
- 血清CIRP与IL-1β,IL-33,ET-1和疾病严重程度正相关,与NO和SpO2负相关,表明COPD-PH的强有力的预测价值.
结论:
- 血清CIRP水平升高与COPD-PH的炎症和内皮功能障碍有关.
- eCIRP作为一个潜在的生物标志物用于预测COPD-PH的内皮功能障碍.
- 血清CIRP,IL-33和ET-1水平是诊断COPD-PH的重要指标.
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