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在患有牙周炎的大群体中,维生素D结合蛋白和受体的患病率:单核酸多态性和转录基因分析

Ziyan Nie^1,2, Xiaopan Hu^2,3, Peinan Hu⁴

¹School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, Gansu, PR China.

BMC oral health

|December 19, 2024

概括

特定的维生素D受体 (VDR) 和结合蛋白 (VDBP) 基因变异,包括rs739837和rs7041,与慢性牙周炎 (CP) 易感性有关. 这些遗传因素可以提供保护,防止发生牙周炎.

科学领域:

遗传学是一个遗传学.
口腔生物学口腔生物学
分子生物学分子生物学

背景情况:

维生素D受体 (VDR) 和结合蛋白 (VDBP) 基因表达和多态性在牙周炎中的作用仍然存在争议.
研究这些遗传因素对于理解牙周炎的发病因子至关重要.

研究的目的:

澄清特定VDR和VDBP基因单核酸多态 (SNP) 和慢性牙周炎 (CP) 之间的关系.
分析CP患者的牙组织中差异性基因表达的转录组数据.

主要方法:

来自307名CP患者和293名健康对照者的基因组DNA使用MassARRAY系统分析了VDR和VDBP基因中的8个SNP.
来自牙组织的转录组测序数据被分析,以确定差异性的基因表达特征.
使用回归分析来评估SNP与CP敏感性之间的关联.

主要成果:

VDR rs739837 (TT基因型) 和VDBP rs7041 (AC/CC基因型,C等位基因) 多态性与降低CP敏感性显著相关.
具有VDR rs739837 TT基因型的个体有47%的CP风险降低 (OR=0.53).
具有VDBP rs7041 AC/CC基因型的个体的风险降低了30% (OR=0.70),C等位基因表现出保护作用 (OR=0.75).
对于其他六个测试的SNP,没有发现显著的关联.
在CP患者的牙组织中观察到不同的VDR转录水平.

结论:

在VDR (rs739837) 和VDBP (rs7041) 的遗传变异显著与患慢性牙周炎的易感性有关.
在VDR中的rs739837 TT基因型和VDBP中的rs7041 A/C多态可能会对牙周炎产生保护作用.
VDR遗传变异性和转录表达在CP发展中发挥作用.

关键词:

慢性牙周炎慢性牙周炎单个核酸的多态性.维生素D结合蛋白是一种维生素D结合蛋白.维生素D的受体是维生素D的受体.

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