评估功能磁共振APT和DKI对乳腺癌的成像
Haiyan Shan1, Tengfei Ke2, Shasha Bao1
1Department of Radiology, Yan 'an Hospital Affiliated to Kunming Medical University, Yan 'an Hospital of Kunming City, Kunming, China.
Cancer cell international
|December 19, 2024
概括
胺基质子转移加权成像 (APTWI) 和扩散形成像 (DKI) 在区分良性和恶性乳腺病变方面表现有前途. DKI与明显扩散系数 (ADC) 映射相结合,为乳腺癌亚型提供了高的诊断准确性.
科学领域:
- 放射学 放射学是一门学科.
- 在瘤学瘤学.
- 医疗成像医学成像
背景情况:
- 准确区分良性与恶性乳腺病变对于有效的患者管理至关重要.
- 定量磁共振成像 (qMRI) 技术为乳腺组织的非侵入性表征提供了潜力.
研究的目的:
- 为了比较胺质子转移加权成像 (APTWI) 和扩散曲解成像 (DKI) 在区分良性和恶性乳腺病变的诊断性能.
- 评估这些技术在评估乳腺癌分子亚型方面的有用性.
- 为了确定定量MRI参数的诊断效果.
主要方法:
- 168名妇女接受了乳房APTWI和DKI.
- 测量了定量MRI参数,包括APT信号强度 (SI),明显的曲解系数 (Kapp),非高斯扩散系数 (Dapp) 和明显扩散系数 (ADC).
- 统计分析包括单向ANOVA和接收器操作特征 (ROC) 曲线分析.
主要成果:
- 与良性病变相比,恶性瘤的Kapp和APTSI值显著更高,ADC和Dapp值较低.
- DKI和ADC映射的组合产生了最高的诊断性能 (AUC = 0.936).
- 与Kapp,Dapp和APT值相比,ADC值在区分乳腺癌分子亚型方面表现优越.
结论:
- APTWI有效地区分良性与恶性乳腺疾病,补充扩散权重MRI.
- DKI,特别是与ADC结合使用时,对乳腺病变具有很高的诊断准确性.
- 虽然APTWI很有价值,但它在识别乳腺癌分子亚型方面并不优于DKI和DWI.
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