杆菌血清阳性,甘油三糖指数和心血管疾病之间的关系:使用NHANES数据库的队列研究
Chunlin Tang1, Qian Zhang1, Chunmei Zhang2
1Department of Gastroenterology, China-Japan Union Hospital of Jilin University, Changchun, 130033, China.
Cardiovascular diabetology
|December 19, 2024
概括
杆菌 (H. pylori) 感染可能会通过甘油三糖指数 (TGI) 间接增加心血管疾病 (CVD) 风险. 这表明H. pylori查和根除可能有利于心血管疾病患者.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 代谢综合征是代谢综合征的一种.
背景情况:
- 杆菌 (H. pylori) 是一种常见的病原体,与心血管疾病 (CVD) 风险有关,尽管相关性仍在争论中.
- 甘油三糖指数 (TGI) 是胰岛素耐药性的指标,可能会影响H. pylori和心血管疾病的关系,但这仍然不清楚.
研究的目的:
- 调查H. pylori血清阳性,TGI和心血管疾病风险之间的关联.
- 探索TGI在H. pylori感染和心血管疾病结局之间的关系中的潜在调解作用.
主要方法:
- 利用了来自国家健康和营养检查调查 (NHANES) III和NHANES (1999-2000) 的数据.
- 使用后勤回归和Cox比例危险模型来评估风险和死亡率.
- 应用受限立方线曲线和调解分析来检查关系和效应.
主要成果:
- 与高TGI (≥75百分位) 结合的H. pylori血清阳性与心血管疾病风险增加有关 (OR=1.487).
- 在心血管疾病患者中,高TGI和H. pylori阳性与较高的全因死亡风险相关 (HR=1.227).
- 杆菌通过TGI.显示出对心脏病发病率和死亡率的显著调解作用.
结论:
- 杆菌血清阳性可能会通过TGI间接提高心血管疾病风险和死亡率.
- 整合H. pylori状态和TGI可以改善心血管疾病和相关死亡率的预测.
- 在心血管疾病患者中查和根除H. pylori可能具有临床益处.
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