生理测量心脏病和中风的变化和风险:来自三个队列研究的证据
Wei Liu1,2,3, Lieyang Fan1,4, Da Shi5
1Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China.
BMC medicine
|December 19, 2024
概括
长期生理测量的变化会增加老年人患心脏病和中风的风险. 这种风险部分是由于肌肉强度降低,血糖高以及功能不佳.
科学领域:
- 老年学是指老年学的学科.
- 心血管医学 心血管医学
- 生物标志物 生物标志物
背景情况:
- 长期生理变异对老年人心血管健康的影响尚未完全理解.
- 关联生理变异与心血管结果的潜在机制需要阐明.
研究的目的:
- 调查长期生理变化与老年人心脏病和中风事件风险之间的关联.
- 探索特定生物标志物在这些关联中的调解作用.
主要方法:
- 从三个大型队列 (查尔斯,HRS,英国生物库) 的老年人中创建了一个生理变异性 (血压,脉率,BMI) 的复合得分.
- 分析了复合得分和发生心脏病/中风之间的关联.
- 使用诸如握力,C反应蛋白,HbA1c和cystatin C等生物标志物进行调解分析.
主要成果:
- 较高的综合分数与队列中心脏病和中风风险增加有关.
- 综合分数每增加1分,心脏病风险增加19%,中风风险增加23%.
- 握力降低,HbA1c升高和cystatin C升高显著介导这些增加的风险.
结论:
- 长期的生理变化是老年人群中心脏病和中风的重要危险因素.
- 肌肉强度,高血糖和功能的生物标志物部分解释了生理变化和心血管事件之间的联系.
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