在欧洲循环死亡后,来自于不受控制的捐赠的固体器官移植:叙述性审查
Yann Pionnier1, Tom Darius2, Andrea Penaloza3
1Emergency Department, Cliniques Universitaires Saint-Luc, Brussels, Belgium. yann.pionnier@gmail.com.
Scandinavian journal of trauma, resuscitation and emergency medicine
|December 19, 2024
概括
循环死亡 (DCD) 后的捐献提供了一个重要的器官来源,特别是来自医院外心脏骤停 (OHCA) 患者的器官. 尽管最初的疗效较低,但不受控制的DCD (uDCD) 的长期结果与其他捐赠类型相似.
科学领域:
- 移植医学 移植医学
- 紧急医疗 紧急医疗
- 器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐赠器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器官捐献器
背景情况:
- 人体器官移植,始于20世纪60年代,面临着全球供体器官短缺.
- 像常温 perfusion 和机器 perfusion 这样的进步提高了来自循环死亡捐赠者的器官活力.
- 医院外心脏骤停 (OHCA) 呈现出一个重要的,但往往尚未开发的,捐赠者池.
研究的目的:
- 审查从循环死亡 (uDCD) 后不受控制的捐赠移植的器官.
- 突出紧急医生在OHCA患者器官捐献过程中的关键作用.
- 评估UDCD在解决器官短缺问题上的成果和潜力.
主要方法:
- 审查欧洲数据库和有关器官采购的观察研究以及DUDD的结果.
- 分析OHCA的发病率和这些病例中器官捐献的可能性.
- 检查当前和新兴的技术,如器官捐献的背景下体外心肺复苏 (E-CPR).
主要成果:
- 不受控制的DCD (uDCD) 显示了较低的短期移植存活率比捐赠脑死亡后 (DBD) 和受控的DCD (cDCD).
- 从UDCD获得的长期移植存活率与cDCD和DBD的结果相似.
- OHCA患者代表了大量的潜在捐赠者,尽管捐赠者数量可能被高估.
结论:
- uDCD为增加器官移植提供了一个有价值的来源,特别是在OHCA场景中.
- 需要进一步的研究来完善捐赠者选择,成本效益分析,以及像E-CPR.这样的技术的整合.
- 紧急医疗服务和部门必须整合到器官捐献途径中,以最大限度地发挥潜力.
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