孕妇甲状腺功能障碍对胎儿和孕妇怀孕后果的影响:一项前性队列研究
Roshni Vamja1, Yogesh M1, Monika Patel1
1Department of Community Medicine, Shri M P Shah Government Medical College, New College Building, GG Hospital Campus, Patel Colony Post, Jamnagar, Gujarat, 361008, India.
孕妇甲状腺功能障碍显著增加了不良妊娠结果的风险,包括早产和孕前. 早期的甲状腺监测和管理对于改善母亲和胎儿健康至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 生殖健康 生殖健康
背景情况:
- 怀孕期间甲状腺功能障碍对母亲和胎儿的健康构成风险.
- 需要明确与母亲甲状腺状况相关的特定不良结果,特别是在研究不足的人群中.
研究的目的:
- 在印度古吉拉特州调查母亲甲状腺功能障碍和胎儿-母亲结果之间的关联.
- 提供关于甲状腺功能低下症和甲状腺功能增强症对妊娠并发症的影响的见解.
主要方法:
- 一项基于医院的前性队列研究,涉及900名孕妇 (500名甲状腺功能低下,250名甲状腺功能低下,150名甲状腺功能高).
- 通过血清TSH和FT4水平评估母亲甲状腺状况.
- 监测的不良结果包括早产,新生儿重症监护室入院,孕前,产后出血和血栓栓塞.
主要成果:
- 甲状腺功能低下的女性患早产风险增加 (RR 1.8),APGAR分数低 (RR 2.5),孕前 (RR 3.0),产后出血 (RR 1.6),静脉血栓栓塞 (RR 3.1).
- 甲状腺功能高的女性有较低APGAR评分 (RR 1.8) 的风险,新生儿低血糖 (RR 1.5),呼吸困难 (RR 1.4),以及产后甲状腺炎 (RR 2.3) 的风险增加.
结论:
- 孕产妇甲状腺功能障碍与明显更高的胎儿和孕产妇不良并发症风险有关.
- 常规的甲状腺功能查和及时的治疗对于减轻妊娠并发症至关重要.
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