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各种格拉姆阴性细菌对抗菌剂的敏感性:中国的SMART 2019-2020年

Ying Fu^1,2, Yueliang Chen^3,4, Yanfei Wang^3,4

¹Department of Clinical Laboratory, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China.

BMC microbiology

|December 19, 2024

概括

格兰阴性细菌 (GNB) 的抗微生物耐药性是中国医院日益关注的问题. 碳胺耐药性因感染部位而异,治疗选择有限,强调需要有效的抗微生物策略.

科学领域:

临床微生物学临床微生物学
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

针对监测抗菌素耐药性趋势的研究 (SMART) 计划跟踪了格拉姆阴性细菌 (GNB) 的抗菌素耐药性.
这项研究更新了2019-2020年中国的GNB发病率和耐药性模式,涉及血液,腹腔,呼吸道和尿路感染.

研究的目的:

分析来自中国各种感染的GNB分离物的发病率和抗菌敏感性.
评估对常用的抗菌剂的耐药性模式.

主要方法:

分析了来自中国22家医院的4975个GNB隔离物 (2019-2020年).
苏微稀释方法用于确定抗微生物最小抑制度.
根据欧洲抗生素敏感性测试委员会2022年或临床和实验室标准协会的断点进行敏感性解释.

主要成果:

大肠杆菌 (32.1%),肺炎菌 (25.3%),肺炎菌 (13.9%) 和菌 (10.5%) 是最常见的GNB.
检测卡巴胺耐药 (CR) 肠杆菌的检测率在10.3% (UTI) 到18.9% (RTI) 之间.
生产扩展谱β-乳酸酶 (ESBL) 的肠杆菌对卡巴胺 (>91.7%),阿米卡辛 (≥87.8%) 和胆固醇素具有很高的敏感性,但对其他药物的敏感性较低.

结论:

在中国的医院中,抗卡巴因的发病率各不相同,限制了治疗选择.
碳烯在体外表现出对ESBL产生肠道细菌的有效活性.
阿米卡辛对CR-Ec和CR-Pa有显著的疗效,但对CR-Kp的疗效较小.

关键词:

它们是Enterobacteriaceae的细菌.耐卡巴胺的肠道细菌.DTR P. Aeruginosa 在美国这就是ESBL.这就是智能智能.

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