竞争风险 艾滋病毒/艾滋病的时间到事件数据分析的多国家模型:回顾性队列国家数据集,埃塞俄比亚
Tsegaye H Kumssa1,2, Andargachew Mulu3, Adane Mihret3
1Department of Statistics, Hawassa University, Hawassa, Ethiopia. tsegaye.hailu@ahri.gov.et.
BMC infectious diseases
|December 19, 2024
概括
结核病 (TB) 仍然是埃塞俄比亚艾滋病毒/艾滋病患者的主要死亡原因,即使有抗逆转录病毒疗法 (ART). 早期检测和治疗对于改善这一脆弱人群的生存率至关重要.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 结核病 (TB) 是埃塞俄比亚艾滋病毒/艾滋病感染者死亡的主要原因.
- 抗逆转录病毒疗法 (ART) 已经减少了死亡率,但结核病仍然是一个重大威胁.
- 了解相互竞争的风险对于管理艾滋病毒/艾滋病和结核病联合感染至关重要.
研究的目的:
- 在接受ART治疗的HIV/AIDS患者中估计结核病死亡的概率.
- 评估预后因素对特定原因死亡的影响.
- 确定该人口中主要的死亡原因.
主要方法:
- 追溯分析来自埃塞俄比亚国家ART计划的39590名患者记录 (2019年10月至2020年3月).
- 使用因果特定危险,分分布危险和灵活的参数比例危险模型.
- 在R4.3.2软件中使用cmprisk包来分析竞争风险.
主要成果:
- 结核病占死亡人数的34.7% (421/1212),死亡率为每1000人月3.5人.
- 较高的CD4细胞计数,ART反应和肺囊性肺炎 (PCP) 预防降低了死亡风险.
- 高龄,晚期艾滋病毒诊断和WHO临床阶段的晚期增加了结核病和其他感染的死亡风险.
结论:
- 结核病是埃塞俄比亚艾滋病毒/艾滋病患者接受ART治疗的主要死亡原因,尽管存在竞争风险.
- 及时检测和有效管理艾滋病毒/艾滋病是改善患者生存的关键.
- 需要有针对性的干预措施来缓解结核病和其他机会性感染风险.
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