美国成年人与代谢功能障碍相关的脂肪性肝病的生命必不可少8和死亡率
Yingying Zhang1, Pingping Wang2, Fan Tu1
1Medical Laboratory Center, Affiliated Wuxi Fifth Hospital of Jiangnan University, No. 1215 Guangrui Road, Jiangsu, 214005, China.
更高的生活必需品8 (LE8) 评分显著降低了与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者的死亡风险. 改善LE8指标,特别是饮食和体育活动,是获得更好的结果的关键.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益关注的问题,与肥胖,糖尿病和心血管疾病的死亡率增加有关.
- 了解减轻MASLD患者死亡风险的因素对于公共卫生倡议至关重要.
研究的目的:
- 研究生活必需8 (LE8) 评分与所有原因和心血管疾病 (CVD) 死亡率在患有MASLD的个体之间的关联.
- 为了确定是否遵守心血管健康指南,以LE8测量,影响MASLD群体的生存率.
主要方法:
- 分析了2005-2018年国家健康和营养检查调查 (NHANES) 中5916名MASLD参与者的数据.
- 考克斯的比例危险模型被用来评估LE8得分和死亡结果之间的关系,并追踪到2019年12月.
- 卡普兰-梅尔曲线和受限立方分线模型评估了剂量反应关系和生存差异.
主要成果:
- 与低得分相比,较高的LE8得分与所有原因死亡率 (33-47%的降低) 和心血管疾病死亡率 (53-65%的降低) 的风险明显降低.
- 在LE8健康行为得分,特别是饮食,体力活动和尼古丁暴露的10点增加,与所有原因和心血管疾病死亡率的11%降低相关.
- 在健康因素中,只有血糖水平与降低心血管疾病死亡风险显著相关.
结论:
- 在MASLD患者中,LE8得分升高与死亡风险降低有关,这凸显了促进心血管健康的重要性.
- 这些发现表明,旨在改善LE8指标的干预措施可能有利于改善MASLD患者的生存率.
- 需要进一步的研究来确认这些关联,并探索具体的干预策略.
更多相关视频
08:41Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
Published on: March 24, 2023
08:35A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
Published on: May 18, 2021
相关概念视频
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Liver Physiology
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of 70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
Liver Regeneration
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
Diseases of the Liver and Gallbladder
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Metabolic States of the Body: Fasting and Starvation
