在中国精神分裂症患者的认知功能,抗氧化剂和临床变量之间存在关联
Dan Li1, Yuanyuan Huang2,3,4, Hongxin Lu5
1Department of Psychiatry, Guangzhou Civil Affairs Bureau Psychiatric Hospital, Guangzhou, 510430, China.
BMC psychiatry
|December 19, 2024
概括
精神分裂症 (SCZ) 的认知功能障碍与低抗氧化剂水平和负面临床症状有关. 专蛋白和超氧化物脱酶水平,以及临床因素,影响SCZ患者的认知表现.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 生物化学 生化学
背景情况:
- 认知功能障碍是精神分裂症 (SCZ) 的一个重大挑战,影响日常功能.
- 认知缺陷,临床因素和SCZ中抗氧化剂状况之间的关系尚不清楚.
研究的目的:
- 为了研究中国精神分裂症患者的认知功能.
- 探索认知表现,临床症状 (使用PANSS) 和抗氧化剂水平 (ALB,UA,SOD) 之间的关联.
主要方法:
- 招募了133名SCZ患者和120名健康对照 (HC).
- 使用 MATRICS 共识认知电池 (MCCB) 评估认知功能.
- 用积极和消极综合征量表 (PANSS) 测量临床症状和量化血/血清抗氧化剂水平.
主要成果:
- 与HC相比,SCZ患者在多个认知领域的MCCB得分明显较低.
- 在SCZ患者中,总PANSS得分和大多数MCCB维度之间观察到负相关性.
- 在SCZ患者中发现了较低的白蛋白 (ALB) 和较高的尿酸 (UA) 和超氧化失调酶 (SOD) 水平;ALB和SOD水平与特定的认知功能相关.
结论:
- 在精神分裂症中,认知功能明显受损.
- 在SCZ的认知缺陷与特定的临床症状和关键抗氧化剂水平的变化有关,如白蛋白和超氧化物脱酶.
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