血液中的重金属与美国成年人便失禁之间的关联:基于人口的研究
Zhigang Li1,2, Siqi Peng3, Decong Zhang3
1The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi Province, Nanchang, China.
BMC public health
|December 19, 2024
概括
暴露于重金属 (HM),特别是 (Cd) 和 (Pb),与美国成年人的便失禁 (FI) 有关. 这项研究强调了血液中HM水平和FI之间的显著关联,特别是.
科学领域:
- 环境健康 环境健康
- 胃肠病学 胃肠病学
- 毒理学 毒理学 毒理学
背景情况:
- 以前的研究表明,重金属 (HMs) 影响肠道健康和肠道结构.
- 暴露于HM和便失禁 (FI) 之间的具体联系尚未得到充分证实.
研究的目的:
- 调查血液HM水平与美国成年人FI患病率之间的关联.
- 探索 (Cd), (Pb) 和 (Hg) 对FI的影响.
主要方法:
- 利用了2005-2010年国家健康和营养检查调查 (NHANES) 的数据.
- 采用加权后勤回归,双指数加权量子量和 (2iWQS) 和量子量g计算 (qgcomp) 来分析HM-FI关系.
- 进行子组分析以确定特定的人口关联.
主要成果:
- 总共分析了12,142名成年人 (≥20岁).
- 在血液中的 (Cd) 和 (Pb) 水平和FI之间发现了积极的关联,在同变量调整后仍然存在.
- 混合HMs,其中Cd是最有影响力的,与FI显示出显著的正相关性 (2iWQS和qgcomp分析).
- 亚组分析显示,男性,墨西哥裔美国人以及具有高等教育或特定健康状况的个人中,Cd-FI的关联更强.
结论:
- 血液HM暴露,特别是,与美国成年人群的便失禁有显著的相关性.
- 需要进一步的研究,以了解这种关联背后的因果路径和生物机制.
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