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与癌症相关的纤维细胞,瘤和放射治疗:瘤微环境中的相互作用

Kris T P M Raaijmakers¹, Gosse J Adema¹, Johan Bussink¹

¹Radiotherapy and OncoImmunology Laboratory, Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.

Journal of experimental & clinical cancer research : CR

|December 19, 2024

概括

癌症相关纤维细胞 (CAFs) 促进瘤生长和治疗耐药性. 针对衰老的CAF是提高癌症治疗效率和预防复发的关键.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
瘤微环境研究研究

背景情况:

癌症相关纤维细胞 (CAFs) 是非恶性树突细胞,占固体瘤的80%左右.
CAFs表现出表型多样性和可塑性,影响瘤生长,入侵和治疗阻力.
虽然CAF可以具有抗瘤原生作用,但它们主要通过信号传递,免疫调节和细胞外矩阵重塑来表现出亲瘤原生功能.

研究的目的:

审查CAF在瘤微环境 (TME) 中的多方面的作用.
专注于CAF的行为和功能,特别是对放射治疗的反应.
突出CAFs在瘤进展和治疗耐药性的重要性.

主要方法:

文献综述专注于CAF生物学和固体瘤中的功能.
分析CAF在放射治疗等治疗干预之前,期间和之后的作用.
讨论目前和拟议的调节CAF活动的策略.

主要成果:

CAFs显著影响瘤的进展,包括生长,入侵和对治疗的抵抗.
放射和化疗等治疗干预措施可以诱导CAF衰老,经常放大它们的前瘤特征.
衰老的CAFs有助于持续的瘤细胞抵抗,ECM调节,上皮细胞转移到介质细胞 (EMT) 和免疫抑制.

结论:

在治疗后的瘤细胞存活,复发和潜在的恶性转变中,CAFs起着至关重要的作用.
在TME中调节CAF功能是提高治疗结果的关键领域.
未来的癌症治疗策略必须在治疗TME中纳入对CAF行为的理解.

关键词:

与癌症相关的纤维细胞.无线电阻可以抵抗辐射.治疗耐药性治疗耐药性瘤微环境是一个微环境.

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