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对于治疗青少年精神疾病的大麻素:随机对照试验的系统审查

Patrick Köck¹, Andrzej Badek², Maximilian Meyer³

¹Department of Psychosomatics and Psychotherapy, Clinic Barmelweid, Barmelweid, Switzerland.

Child and adolescent psychiatry and mental health

|December 19, 2024

概括

大麻素对年轻人的心理健康,特别是自闭症谱系障碍,显示出适度的益处. 然而,需要更多的研究来确认疗效,并制定这些疾病的治疗指南.

科学领域:

精神病学是一个精神病学.
神经科学是一个神经科学.
药理学药理学是指药理学的学科.

背景情况:

大麻素正在越来越多地研究其在精神病,精神病和神经疾病中的潜在疗效.
对它们在治疗精神疾病中的治疗应用越来越感兴趣.

研究的目的:

系统地审查随机的安慰剂受控试验对大麻素的疗效和剂量精神疾病在0-25岁的个体.
综合用于儿科和年轻成人心理健康中的大麻素治疗方法的证据.

主要方法:

在2024年6月30日之前对PubMed和Embase进行系统审查,遵守PRISMA指南.
包括将大麻素疗法与0-25岁个体的对照进行比较的RCT.
对主要结果的效果大小 (Hedges' g) 的元分析,使用多级随机效应建模.

主要成果:

八项试验 (474名参与者) 符合资格标准,显示症状改善的适度积极总体效应 (g=0.308).
自闭症谱系障碍研究显示了最一致的证据 (g=0.264).
成年人群表现出比儿科人群更高的效果大小;整个植物和制药类大麻素显示出类似的效果. 没有发现CBD剂量和效果大小之间的显著相关性. 报告了轻微的副作用,没有严重的不良事件.

结论:

分析表明,大麻素对主要结果,特别是自闭症谱系障碍的温和积极影响.
目前的证据不足以为青少年心理健康治疗提供广泛建议.
为了建立明确的临床指导方针,需要进行更大规模的,具有标准化结果的受控研究.

关键词:

自闭症谱系障碍自闭症谱系障碍大麻二醇 (Cannabidiol) 是一种这是一种大麻素 (cannabinoid).大麻治疗大麻治疗.精神障碍精神障碍是一种精神障碍.精神病性疾病精神病性疾病年轻人年轻人年轻人年轻人年轻人

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