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洞察PRRSV爆发期间小猪生存的遗传决定因素

Joaquim Tarrés¹, Teodor Jové-Juncà², Carles Hernández-Banqué²

¹Animal Breeding and Genetics Program, Institute of Agrifood Research and Technology (IRTA), Caldes de Montbui, Spain. joaquim.tarres@irta.cat.

Veterinary research

|December 19, 2024

概括

养殖猪的疾病耐药性补充了生物安全. 基因标记物和免疫特征,如IgG水平和SOX13mRNA,可以预测猪生殖和呼吸系统综合征病毒 (PRRSV) 爆发期间的生存率.

科学领域:

动物遗传学动物遗传学
免疫学免疫学免疫学
兽医科学兽医科学兽医科学

背景情况:

猪生殖和呼吸系统综合征病毒 (PRRSV) 在猪生产中带来了重大经济挑战.
传统的疾病控制依赖于生物安全和疫苗接种,但为了增强耐药性而进行育种提供了一个补充策略.
遗传变异性影响疾病耐药性,使其成为改善猪群健康的目标.

研究的目的:

评估遗传标记和免疫参数在自然PRRSV爆发期间对猪生存的预测能力.
确定与杜洛克猪中PRRSV耐药性相关的特定遗传标记和免疫特征.
了解敏感等位基因对小猪生存率的累积影响.

主要方法:

一组129只Duroc小猪队自然感染了PRRSV基因型1株.
感染前的查包括血IgG水平,血液SOX13mRNA表达,以及使用132个单核酸多形态 (SNP) 的20个细菌的基因定型.
进行了生存分析,将免疫参数和 sire SNP 基因型与小猪死亡率相关联.

主要成果:

较低的基底IgG水平和高的SOX13mRNA表达与明显更高的死亡率有关.
特定的SNP与免疫特征 (例如IgG,CRP,淋巴细胞计数) 相关,可显著预测后代的存活率.
标记物CD163和GBP5也与小猪的存活率有关.
在多个标志物中积累敏感基因的累积累计降低了生存率,从94%降至21%.

结论:

猪的遗传变异性显著影响了PRRSV感染后的生存率.
已识别的遗传标记和免疫参数可用于在育种计划中选择PRRSV耐药性.
这项研究为开发更强壮和抗病的猪种群提供了基础.

关键词:

PRRSVV 在这个问题上.在SNP中,SNP是SNP.疾病疾病疾病疾病遗传标记物遗传标记物免疫反应的免疫反应.免疫特征免疫特征免疫特征幸存率幸存率生存率

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