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Updated: May 31, 2026

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基于咖啡酸的二叶酸减少酶抑制剂的分子建模,合成和生物评估

Renu Sehrawat1, Ritu Pasrija2, Priyanka Rathee3

  • 1School of Medical & Allied Sciences, K. R. Mangalam University, Gurugram, 122103, Haryana, India.

BMC chemistry
|December 19, 2024
PubMed
概括

新的咖啡酸衍生物被合成并测试为二叶酸减少酶 (DHFR) 抑制剂. 化合物CE11显示出强烈的抗癌活性,而CE3和CE15显示出对各种细菌具有显著的抗微生物特性.

关键词:
二基叶酸减少酶抑制剂这是一种抗癌药物.抗微生物药物 抗微生物药物抗微生物耐药性 抗微生物耐药性咖啡酸是一种咖啡酸.药物设计 药物设计分子对接是分子对接.

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