在2型糖尿病的成年人中,狭窄范围的时间和发生的糖尿病视网膜病变之间的关联
Yaxin Wang1, Jingyi Lu1, Jiamin Yu1
1Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China.
Diabetes, obesity & metabolism
|December 19, 2024
概括
狭窄范围的时间 (TITR) 与2型糖尿病患者的糖尿病视网膜病变发病率相反相关. 即使总体葡萄糖控制良好 (TIR),TITR也为视网膜病变风险提供了额外的预测价值.
科学领域:
- 内分泌学 在内分泌学.
- 糖尿病学 糖尿病学
- 眼科医生 眼科 眼科
背景情况:
- 葡萄糖范围中的时间 (70-180 mg/dL) 是一个关键的血糖控制指标.
- 关于在更窄的范围 (70-140 mg/dL) 中强调时间,以获得更好的结果,存在争论.
- 糖尿病视网膜病变是糖尿病的一个主要并发症.
研究的目的:
- 评估时间在狭窄范围 (TITR) 和发生糖尿病视网膜病变之间的关联.
- 为了比较TITR与视网膜病变风险范围内的时间 (TIR) 的预测值.
主要方法:
- 对2518名2型糖尿病成年人进行动态队列研究,在基线没有视网膜病变.
- 使用连续血糖监测数据测量TITR.
- 考克斯比例危险回归分析以评估TITR与视网膜病变发病率的关联.
主要成果:
- 较高的TITR与发生糖尿病视网膜病变的风险较低有关.
- 10%的TITR下降将视网膜病变的风险增加9% (HR=1.09).
- 即使在具有良好控制的TIR (> 70%, > 80%, > 90%) 的子组中,TITR仍然是视网膜病变的显著预测因素.
结论:
- 狭窄范围的时间 (TITR) 是2型糖尿病中糖尿病视网膜病变发病率的显著逆预测指标.
- TITR为视网膜病变风险提供了额外的预后价值,特别是在具有良好的整体血糖控制 (TIR) 的患者中.
相关概念视频
01:15Diabetes: Symptoms, Diagnosis, and Complications
503
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
503
01:22Photoreceptors and Visual Pathways
5.6K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
5.6K
01:20Pathophysiology of Diabetes
862
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
862
01:19Psychoneuroimmunology: Diabetes and Cancer
23
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
23