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Updated: Jun 4, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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探索发现新型CDK12抑制剂的探索

Abhijit Debnath1, Rajesh Kumar Singh2, Rupa Mazumder1

  • 1Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, India.

Journal of receptor and signal transduction research
|December 19, 2024
PubMed
概括

研究人员确定了一种新型小分子,ZINC11784547,作为循环林依赖激酶12 (CDK12) 的强有力的抑制剂. 这种化合物通过有效抑制癌细胞生长和促进细胞死亡,对癌症治疗具有前景.

关键词:
在CDK12中,CDK12就是CDK12.达成共识的分子对接尤文肉瘤 (Ewing Sarcoma) 是一种癌症.癌症 癌症 癌症 癌症 癌症前列腺癌是前列腺癌.

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