分析:全球发病率和死亡率的肝硬化在代谢功能障碍相关的脂肪性肝病
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Soroor Owrangi1, James M Paik1,2,3, Pegah Golabi1,2,3
1Beatty Liver and Obesity Research Program, Inova Health System, Falls Church, Virginia, USA.
Alimentary pharmacology & therapeutics
|December 19, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 肝硬化是常见的,在全科医院影响全球3.26%,在高风险环境中影响14.51%. 这凸显了对MASLD患者更好的查和管理的需要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个重大的全球健康挑战.
- 与MASLD相关的肝硬化病的确切患病率和死亡率尚未确定,这阻碍了有效的公共卫生干预.
研究的目的:
- 为了估计MASLD患者中肝硬化的全球患病率.
- 确定与MASLD相关的肝硬化相关的全球死亡率.
主要方法:
- 在主要数据库 (PubMed,MEDLINE,EMBASE,Web of Science,SCOPUS) 进行了系统的文献搜索,截至2024年6月.
- 研究被分为一般实践和高风险环境 (住院或转诊进行活检).
- 一个随机效应模型被用来进行分析,遵循PRISMA指南.
主要成果:
- 35项涉及513,742名患者的研究符合纳入标准.
- 在MASLD中,肝硬化的全球患病率为3.26% (一般实践) 和14.51% (高风险环境).
- 在高风险群体中,北美/澳大利亚 (18.38%) 与欧洲 (10.16%) 和亚洲 (9.12%) 的患病率较高. 基于ICD的诊断显示患病率 (27.43%) 比通过活检诊断 (13.24%) 高. 所有原因的死亡率为每100人年7.91.
结论:
- 与MASLD相关的肝硬化在全球有相当大的患病率,具有显著的区域和诊断差异.
- 调查结果表明,对于MASLD患者来说,急需加强查方案和管理策略.
- 改善公共卫生策略是必要的,以应对与MASLD相关的肝硬化病的负担.
关键词:
马什 (MASH) 是一个非常重要的产品.马斯尔德 马斯尔德是什么意思这是NAFLD.纳什·纳什 (Nash Nash) 是一个名为纳什的城市.先进的纤维化.肝硬化是肝硬化的一种疾病.死亡率 死亡率更多相关视频
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