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在1期缺乏梅拉素的小鼠骨表型

Olaf Bahlmann1, Shahed Taheri2, Manuela Spaeth3

  • 1Faculty of Medicine, Institute for Anatomy II, Goethe University Frankfurt, Frankfurt am Main, Germany.

Journal of pineal research
|December 19, 2024
PubMed
概括

在小鼠中,时钟基因Period-1缺乏导致骨大小和密度较小,特别是在脊柱和后肢. 这项研究揭示了身体表型的改变,并影响了骨矿化.

关键词:
骨密度 骨密度 骨密度时钟基因的时间基因微计算机断层扫描 (microcomputed tomography) 是一种微计算机断层扫描技术.时期-1;体型调节;骨化;骨化.

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Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...