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通过GLS1抑制的老化通过诱导过度的mPTP通过MFN1打开来改善脏衰老

Yuting Chen^1,2, Nan Zhao^1,2, Yu Zhang^1,2

¹Division of Nephrology, Department of Geriatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

The journals of gerontology. Series A, Biological sciences and medical sciences

|December 19, 2024

概括

向谷氨酸酶1 (GLS1) 通过诱导线粒体功能障碍来消除衰老的细胞. 这种新的老化策略对治疗与年龄相关的脏疾病充满希望.

科学领域:

细胞生物学细胞生物学
老年学是一门学科.
生物化学生化学

背景情况:

细胞衰老驱动衰老和相关疾病.
老化,即老化的细胞的消除,是一种潜在的治疗方法.
谷氨酸酶1 (GLS1) 在衰老的管状上皮细胞 (TEC) 中的作用尚不清楚.

研究的目的:

研究GLS1在老化的TEC中的作用和机制.
探索GLS1抑制作为衰老相关脏疾病的老化策略.

主要方法:

使用d-银糖诱导HK-2细胞的衰老.
使用GLS1抑制剂BPTES和MFN1敲击.使用GLS1抑制剂BPTES和MFN1敲击.
向老年小鼠服用BPTES以评估体内疗效.

主要成果:

在衰老的TEC中GLS1抑制促进了过度的线粒体透性过渡孔 (mPTP) 开放.
MFN1上调与过度的mPTP开放和转向线粒体融合有关.
在老年小鼠中GLS1抑制清除了衰老的TEC,改善了功能.

结论:

通过过度的mPTP开放,GLS1抑制消除了老化的TEC,这种开放由MFN1.1介导.
向GLS1代表了与年龄相关的脏疾病的潜在老化疗法.

关键词:

在 GLS1 中使用.脏老化的衰老 MFN1 一个国家.衰老分析 (Senolysis) 是一个非常重要的过程.mPTPTP 这是一个很好的方法.

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