产前大麻使用与发育迟缓风险之间的关联评估
Dana Watts1, Catherine Lebel1,2,3, Kathleen Chaput1
1University of Calgary, Calgary, Alberta, Canada.
JAACAP open
|December 19, 2024
概括
产前大麻暴露与婴儿中父母报告的沟通延迟的风险较高有关,尽管在多次比较后,这并不显著. 需要更多的研究来证实这些关于婴儿发育的发现.
科学领域:
- 围产期健康 围产期健康
- 发育儿科 发育儿科
- 公共卫生 公共卫生
背景情况:
- 关于产前大麻暴露和婴儿发育迟缓,存在相互矛盾的研究.
- 以前的研究可能已经过时,或缺乏对混因素的调整.
- 本研究探讨了当代群体中的这些局限性.
研究的目的:
- 调查产前大麻暴露与12个月后父母报告的发育迟缓之间的关联.
- 为了调整现代研究人口中常见的混变量.
- 检查对特定发展领域的影响.
主要方法:
- 利用了来自10695名参与者在COVID-19流行病期间怀孕 (PdP) 研究中的数据.
- 一个子组 (n=3,742) 在12个月完成了年龄和阶段问卷 (ASQ-3).
- 倾向性得分权重和G计算被用于分析关联,调整社会人口统计差异.
主要成果:
- 产前大麻暴露与出生结果 (妊娠年龄,出生体重) 没有关联.
- 在多重比较调整之前,与家长报告的通信延迟 (p=.02) 发现了显著的关联.
- 没有其他发育领域与产前大麻暴露有显著的关联.
结论:
- 产前大麻暴露显示了与沟通延迟的初步关联,但经过多次比较调整后,这种情况不再成立.
- 这些发现并不支持怀孕期间使用大麻对婴儿发育的安全性.
- 建议通过专门针对这些结果的研究设计进行进一步研究.
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