内法里西马布用于先前治疗的神经血管与年龄相关的黄斑变性
Abraham Hang1, Taylor Ngo1, Jaipreet Singh Virk1
1Department of Ophthalmology & Vision Science, University of California Davis Eye Center, Sacramento, CA, USA.
Clinical ophthalmology (Auckland, N.Z.)
|December 19, 2024
概括
在新血管与年龄相关的黄斑变性 (nAMD) 患者中,内法利西马布增加了治疗间隔,并减少了视网膜厚度. 然而,它没有改善视觉敏度,并且它对视网膜厚度的有效性可能会降低在以前接受过多种抗VEGF治疗的患者中.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 神经血管与年龄相关的黄斑变性 (nAMD) 是导致视力丧失的主要原因.
- 抗血管内皮生长因子 (抗VEGF) 疗法是nAMD的标准治疗方法.
- 法里西马布是一种新的抗VEGF疗法,具有延长治疗间隔的潜力.
研究的目的:
- 评估在nAMD患者中内法里西马布的实际有效性,这些患者之前接受过其他抗VEGF药物的治疗.
- 为了评估视觉敏度的变化,中央子场厚度 (CST) 和法里西马布治疗后的治疗间隔.
主要方法:
- 这是一项回顾性,单中心研究,涉及73名nAMD患者的88只眼睛.
- 患者先前接受过各种抗VEGF疗法治疗.
- 收集的数据包括最佳校正的视敏度 (BCVA),CST和法里西马布治疗前和期间的注射间隔.
主要成果:
- 在法里西马布治疗期间,平均BCVA保持稳定 (20/63) (p=0.11).
- 平均治疗间隔从6.1周增加到7.4周 (p<0.001),平均CST从291微米减少到262微米 (p<0.001).
- 之前使用多种抗VEGF药物的治疗与较小的CST减少有关 (p=0.04).
结论:
- 在先前接受过nAMD治疗的眼睛中,内法利西马布增加了治疗间隔和减少了CST,但没有改善BCVA.
- 在接受多种不同的抗VEGF疗法的患者中,CST的减少可能不那么明显.
- 法里西马布表现出良好的安全性概况,由于各种原因,在26.1%的眼睛中断治疗.
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