针对局部晚期和转移性基底细胞癌的免疫疗法:叙述性综述
Xiaoqing Li1,2, Hongru Wang1, Qingli Lu2,3
1Department of Dermatology, The First Affiliated Hospital of Jinan University, Guangzhou, China.
Translational cancer research
|December 19, 2024
概括
基底细胞癌 (BCC) 免疫疗法对晚期和转移性病例显示出前景. 研究强调了免疫微环境因素,SOX2和MMP等生物标志物,以及包括检查点抑制剂在内的新兴治疗方法.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 基底细胞癌 (BCC) 是人类最常见的癌症,在手术后经常复发.
- 局部晚期 (laBCC) 和转移性 (mBCC) 形式可能需要全身治疗.
- 瘤免疫疗法对laBCC和mBCC越来越有效.
研究的目的:
- 审查BCC.中的免疫微环境特征.
- 为了确定BCC的预后生物标志物.
- 总结目前和新兴的BCC免疫疗法.
主要方法:
- 在PubMed和Web of Science数据库中进行文献搜索.
- 从2013年到2024年,包括所有类型的英语学习.
- 专注于免疫微环境,生物标志物和免疫疗法.
主要成果:
- 免疫微环境的改变是BCC进展的关键.
- SOX2和MMP是潜在的预后生物标志物和治疗点.
- 免疫疗法包括PD-1/PD-L1抑制剂,CTLA-4阻断,LAG-3抑制,CAR-T细胞和疫苗.
- 塞米普利马布是首个批准用于耐火性BCC的免疫疗法.
结论:
- 免疫疗法在BCC中显示出临床疗效.
- 需要进一步的大规模,多中心的研究来确认有效性和安全性.
更多相关视频
09:01Analysis of Human T Cell Activity in an Allogeneic Co-Culture Setting of Pre-Treated Tumor Cells
Published on: March 7, 2025
288
11:02Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
21.2K
相关概念视频
Tumor Immunotherapy
475
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
475
Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Skin Cancer
3.1K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.1K
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
