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在细胞外囊泡的in vivo追踪技术方面的研究进展

Yanhua Shi^1,2,3,4, Xianghui Wang^1,5,4, Shifang Zhang⁶

¹School of Bioscience and Technology, Weifang Medical University, Weifang 261053, Shandong, China.

Extracellular vesicles and circulating nucleic acids

|December 19, 2024

概括

细胞外囊泡 (EVs) 对于细胞通信至关重要,并且正在探索治疗方法. 本综述涵盖了分子成像技术,用于追踪生物体内的EV,以了解它们的生物作用.

科学领域:

生物医学科学生物医学科学
细胞生物学细胞生物学
分子成像分子成像技术

背景情况:

细胞释放含有蛋白质和核酸的细胞外囊泡 (EV),调解细胞与细胞的通信.
电动汽车参与了许多生理和病理过程.
了解EV功能对于开发基于EV的疗法至关重要.

研究的目的:

审查*in vivo*细胞外囊泡追踪的典型应用.
讨论分子成像在追踪生物体内EVs中的作用.

主要方法:

采用了分子成像技术,包括生物发光,光,MRI,SPECT,PET,光声学和多式成像.
每种技术都为*in vivo*电动汽车追踪提供了明显的优点和缺点.

主要成果:

在体内追踪EV对于理解基于EV的治疗机制至关重要.
分子成像技术使生物体内的EV实时可视化和跟踪成为可能.

结论:

分子成像是*in vivo*细胞外囊泡研究的强大工具.
对EV追踪应用的进一步研究可以推进治疗策略.

关键词:

细胞外囊泡中的细胞外囊泡.在活体中追踪分子成像分子成像技术这是一个多式联络模式.

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