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在接受免疫治疗的患者中,AXL和/或MITF黑色素瘤亚群的变化

M Willemsen¹, J Bulgarelli², S K Chauhan³

¹Department of Dermatology and Netherlands Institute for Pigment Disorders, Amsterdam University Medical Centers, Location AMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam, The Netherlands.

Immuno-oncology technology

|December 19, 2024

概括

瘤异质性会影响免疫疗法反应. 这项研究发现,虽然MITF+黑色素瘤细胞在免疫疗法下降,但AXL+细胞保持稳定,这表明AXL+细胞可能对治疗有抗性.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
遗传学是一个遗传学.

背景情况:

瘤异质性对有效的癌症疗法,特别是免疫疗法提出了挑战.
AXL+ 瘤细胞对向治疗具有抗性,而 MITF+ 瘤细胞对 RAF 和 MEK 抑制剂有反应.

研究的目的:

分析转移组织中的瘤异质性.
调查AXL+和MITF+黑色素瘤亚种群的存在和行为.
为了将这些子群体与免疫压力和对免疫治疗的反应相关联.

主要方法:

纳米弦基因表达分析分析
单细胞RNA测序的一个细胞.
在现场的多重免疫光.
免疫治疗反应的分析 (免疫调节抗体,树突细胞疫苗接种)

主要成果:

观察到治疗诱导的变化具有显著的患者间变异性.
在转移性组织中的mRNA和蛋白质水平上确定了AXL+和MITF+亚群.
免疫疗法使MITF+黑色素瘤细胞减少,而AXL+细胞保持稳定.
MITF+细胞与CD8+ T细胞呈现逆相关性.
在AXL+或MITF+细胞丰度的变化与改善的生存率没有相关.

结论:

免疫疗法有效地准MITF+黑色素瘤细胞.
AXL+瘤细胞可能会对免疫疗法表现出抗性,类似于它们对向治疗的抗性.

关键词:

一个AXL一个AXL 疫苗接种DCDC 疫苗接种美国MITF MITF 免疫检查点是一个检查点.黑色素瘤是一种黑色素瘤.瘤异质性的异质性

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