在成年人患有正常血糖症的内脏脂肪指数和糖尿病之间非线性剂量反应关系:一项队列研究
Xiaomin Liang1, Zemao Xing1, Ying Li1
1Department of Critical Care Medicine, Shenzhen Second People's Hospital, Shenzhen, Guangdong, China.
内脏脂肪指数 (VAI) 与日本成年人糖尿病风险增加有关. 降低VAI,特别是低于4.67,可能会显著降低患2型糖尿病的几率.
科学领域:
- 代谢健康 代谢健康
- 糖尿病 流行病学 流行病学
- 肥胖问题研究研究
背景情况:
- 以前的研究表明,内脏脂肪指数 (VAI) 和糖尿病之间存在联系.
- 这项研究专门研究了日本一个正常血糖的成年人群中的这种关联.
研究的目的:
- 为了检查内脏脂肪指数 (VAI) 与日本成年人糖尿病发病率之间的关系.
- 确定关联是线性的还是非线性的,并评估VAI对糖尿病发展的预测价值.
主要方法:
- 从2004年到2015年在日本进行了一项纵向队列研究 (NAGALA).
- 采用多变量考克斯回归,受限立方线 (RCS) 模型和ROC曲线分析.
- 这项研究分析了15452名正常血糖成年人的数据.
主要成果:
- 在VAI和发病糖尿病 (HR=1.13) 之间发现了积极的非线性关联.
- 在VAI=4.67时观察到一个转折点;低于这个值的值显示出更强的关联 (HR=1.24每单位增加).
- 这种关联在女性中更明显,VAI显示出良好的预测能力 (AUC=0.7479).
结论:
- 这项研究证实了VAI与日本成年人糖尿病之间的积极,非线性联系.
- 低于4.67的VAI表示一个关键值,其中VAI降低可以显著降低糖尿病风险.
- 这些发现强调VAI是糖尿病风险的有价值标志物,特别是在女性中.
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