相关实验视频
Updated: Jun 4, 2025

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
不同补充剂对哈西莫托甲状腺炎的影响:系统性审查和网络元分析
Bingcong Peng1, Weiwei Wang1, Qingling Gu1
1Department of Endocrinology and Metabolism, The Institute of Endocrinology, National Health Commision of the People's Repiublic of China (NHC) Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, China.
补充剂显著减少了哈西莫托甲状腺炎 (HT) 患者的甲状腺自身抗体. 其他补充剂,如维生素D和myo-inositol没有显著的影响,表明作为HT的有益辅助治疗.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
背景情况:
- 哈西莫托甲状腺炎 (HT) 是一种自身免疫性疾病,其特征是甲状腺自身抗体升高.
- 食补充剂正在探索它们降低HT患者自身抗体水平的潜力.
- 目前关于各种补充剂降低甲状腺自身抗体的疗效的证据各不相同.
研究的目的:
- 系统地审查和比较不同食补充剂在降低甲状腺自身抗体标位 (TPOAb和TgAb) 和恢复HT患者的TSH水平方面的有效性.
- 评估,维生素D,肌肉中毒醇和肌肉中毒醇与的组合对甲状腺自身免疫的影响.
主要方法:
- 使用PubMed,Web of Science,Embase和Cochrane数据库以及CNKI进行了系统的文献审查.
- 包括的研究集中在治疗,维生素D,myo-inositol或myo-inositol加的轻甲状腺HT患者上.
- 通过使用标准化平均差异 (SMD) 和随机效应模型,综合了10项病例控制研究的定量元分析数据.
主要成果:
- 与安慰剂相比,补充剂显著降低了甲状腺过氧化酶自身抗体 (TPOAb) (SMD: -2.44) 和甲状腺蛋白自身抗体 (TgAb) (SMD: -2.76) 的数量.
- 单独使用Myo-inositol,维生素D以及Myo-inositol与的组合,在6个月的治疗期内没有显示出TPOAb或TgAb水平的显著降低.
- 对Myo-inositol,维生素D和Se+Myo-inositol的置信区间表明,对自身抗体减少没有统计学上显著的影响.
结论:
- 补充是有效的降低甲状腺自身抗体水平,在患者与哈希莫托的甲状腺炎.
- 其他研究的补充剂 (维生素D,Myo-inositol) 在本次元分析中没有显示出降低自身抗体的显著益处.
- 被推作为一个适当的辅助治疗,与标准护理一起,为患有哈西莫托的甲状腺炎的患者.
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